What is amitriptyline?
Amitriptyline is a tricyclic antidepressant used to treat symptoms of depression (FDA approved), and amitriptyline is used off-label for insomnia, migraine prevention, ADHD, eating disorders, bipolar disorder, anxiety, psychotic disorders, and some types of pain. Ami-trip-tyline may work by increasing chemical messengers (neurotransmitters) serotonin and norepinephrine that communicate between brain cells and help regulate mood.
The first amitriptyline brand was Elavil, which was FDA-approved on April 7, 1961, and has since been discontinued. Other amitriptyline brand names include Vanatrip and Endep, which have also been discontinued. Ami-tri-ptyline is now available as a generic medication. Amitriptyline is from the drug class tricyclic antidepressants (TCA).
Amitriptyline is available in combination with chlordiazepoxide for the treatment of patients with moderate to severe depression associated with moderate to severe anxiety. Amitriptyline, in combination with perphenazine, is FDA-approved for types of severe anxiety and/or agitation.
ami-tri-ptyline side effects
Allergic reactions: Get emergency medical help if you have signs of an allergic reaction to amitriptyline, including difficulty breathing, hives, or swelling of your face, lips, tongue, or throat.
Report any new or worsening symptoms to your doctor, such as mood or behavior changes, anxiety, panic attacks, trouble sleeping, or if you feel impulsive, irritable, agitated, hostile, aggressive, restless, hyperactive (mentally or physically), more depressed, or have thoughts about suicide or hurting yourself.
Call your doctor at once if you have:
- signs of a blood clot – sudden numbness or weakness, problems with vision or speech, swelling or redness in an arm or leg;
- unusual thoughts or behavior;
- a light-headed feeling, like you might pass out;
- chest pain or pressure, pain spreading to your jaw or shoulder, nausea, sweating;
- pounding heartbeats or fluttering in your chest;
- confusion, hallucinations;
- a seizure (convulsions);
- painful or difficult urination;
- severe constipation;
- easy bruising, unusual bleeding, or
- fever, chills, sore throat, mouth sores.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.
Store at room temperature away from moisture and heat. Keep the bottle tightly closed when not in use.
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